Drosophila Distal-less and Rotund Bind a Single Enhancer Ensuring Reliable and Robust bric-a-brac2 Expression in Distinct Limb Morphogenetic Fields
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منابع مشابه
Drosophila Distal-less and Rotund Bind a Single Enhancer Ensuring Reliable and Robust bric-a-brac2 Expression in Distinct Limb Morphogenetic Fields
Most identified Drosophila appendage-patterning genes encode DNA-binding proteins, whose cross-regulatory interactions remain to be better characterized at the molecular level, notably by studying their direct binding to tissue-specific transcriptional enhancers. A fine-tuned spatio-temporal expression of bric-a-brac2 (bab2) along concentric rings is essential for proper proximo-distal (P-D) di...
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15 صفحه اولDROSOPHILA DISTAL-LESS Distal-less function
Distal-less function Distal-less (Dll), as its name suggests, is required for distal limb development. Drosophila mutants lacking Dll function die as embryos because they lack the rudimentary larval limbs (Cohen and Jurgens, 1989). Viable combinations of Dll alleles of increasing severity can be used to generate a phenotypic series in which weak allelic combinations lead to fusions of the dista...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2013
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1003581